Ellagic Acid Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting Wnt Signaling Pathway

Idiopathic pulmonary fibrosis is a progressive lung disease with high mortality and limited therapy that characterized by epithelial cell damage fibroblast activation. Ellagic acid natural polyphenol compound widely found in fruits nuts has multiple pharmacological activities. In this study, we explored the potential effects mechanisms of on vivo vitro . studies showed significantly alleviated bleomycin (BLM)-induced mice. experiments indicated could suppress Wnt signaling attenuate Wnt3a-induced myofibroblast activation phosphorylation Erk2 Akt. Further induce autophagy formation myofibroblasts mainly suppressing mTOR promoting apoptosis myofibroblasts. revealed inhibited promoted formation. Taken together, our results show effectively attenuates BLM-induced mice inhibiting pathway.